Spontaneous type 1 ECG and arrhythmic risk in Brugada syndrome: A meta-analysis of adjusted time-to-event data.

ABSTRACT:

Background

Brugada syndrome (BrS) is associated with an increased risk of major arrhythmic events (MAEs), particularly in patients with a spontaneous type 1 electrocardiographic (ECG) pattern.

Objective

Because previous meta-analyses used mainly crude or unadjusted data from observational studies, we conducted an updated meta-analysis on the prognostic role of spontaneous type 1 ECG in BrS patients combining adjusted and unadjusted data separately.

Methods

We conducted a systematic search of PubMed and Cochrane Central Register of Controlled Trials from inception to May 2024. Studies providing hazard ratios for MAEs associated with spontaneous type 1 ECG in BrS patients were included.

Results

Eighteen studies comprising 7238 patients were included, with 10 prov

SUBMITTER: Chiotis S 

PROVIDER: S-EPMC11993785 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature