EGFR_{Cystatin C}, difference between eGFR_{Cystatin C} and eGFR_Cre and heart failure: Insight from the NHANES 2001-2002 and Mendelian randomization analysis.

ABSTRACT:

Aim

Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFR_{Cystatin C}), and the difference between Cystatin C and creatinine based eGFR (eGFR_diff) has been suggested to be associated with cardiovascular disease. However, the association between eGFR_{Cystatin C},eGFR_diff and heart failure (HF) risk has not been elucidated in a relatively healthy cohort.

Methods

We used cohort study data from the NHANES 2001-2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFR_{Cystatin C} & eGFR_diff, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. In

SUBMITTER: Gu Z 

PROVIDER: S-EPMC11993832 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature