Frailty as a mediator of postoperative delirium in older adults undergoing orthopedic surgery: A causal mediation analysis.

ABSTRACT:

Background

Postoperative delirium has a high prevalence in hospitalized older adults. Frail older adults have an increased risk for developing it. Preoperative pain-a common symptom in older adults with orthopedic conditions-shows a connection with frailty through an inflammatory process. However, an association among preoperative pain, frailty, and postoperative delirium remains unexplored among older adults undergoing orthopedic surgery.

Objectives

To examine the magnitude, direction, and mediation effect of frailty on the association between preoperative pain and postoperative delirium among older adults undergoing orthopedic surgery.

Design

A secondary analysis of a prospective cohort study.

Setting and participants

A cohort of 200 older adults (60 years an

SUBMITTER: Roopsawang I 

PROVIDER: S-EPMC11993838 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature