Mucosal-associated invariant T (MAIT) cell responses in <i>Salmonella enterica</i> serovar Typhi strain Ty21a oral vaccine recipients.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells are unconventional innate-like T cells abundant in human mucosal tissues and are associated with protective responses to microbial infections. MAIT cells have the capacity for rapid effector functions, including the secretion of cytokines and cytotoxic molecules. In this study, we examined the longitudinal circulating MAIT cell response to the live attenuated oral vaccine Ty21a (Ty21a) against Salmonella enterica serovar Typhi (S. Typhi). We enrolled healthy adults who received a course of oral live-attenuated S. Typhi strain Ty21a vaccine and assessed peripheral blood MAIT cell longitudinal responses pre-vaccination, and at seven days and one-month post-vaccination, using flow cytometry, cell migration, and tetramer decay as

SUBMITTER: Trivedi S 

PROVIDER: S-EPMC11993846 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature