Predictive value of blood urea nitrogen to creatinine ratio and estimated plasma volume status in heart failure.

ABSTRACT:

Background

The blood urea nitrogen to creatinine ratio (BCR) and estimated plasma volume status (ePVS) may be prognostic markers in heart failure (HF), but their combined efficacy is unclear. This research aims to determine the prognostic utility of BCR and ePVS in critically ill HF patients in the intensive care unit.

Methods

Data from the MIMIC-IV database were analyzed. ePVS was calculated using hemoglobin and hematocrit levels with Strauss-derived Duarte method. The primary outcome was 1-year all-cause mortality (ACM). Receiver operating characteristic (ROC) curves identified cutoff values for BCR and ePVS. To assess the connection between BCR, ePVS, and 1-year ACM, the Kaplan-Meier (KM) method, Cox proportional hazards models, subgroup analysis, and limited cubic spline

SUBMITTER: Zheng X 

PROVIDER: S-EPMC11993939 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature