Predicting disease-specific survival in patients undergoing active surveillance for papillary thyroid carcinoma.

ABSTRACT:

Background

American Thyroid Association guidelines support active surveillance (AS) for low-risk papillary thyroid cancer (PTC). We developed a calculator to aid patient selection.

Methods

From 2004 to 2020, 148,904 PTC patients were selected from the surveillance, epidemiology, and end results (SEER) database. Univariable and multivariable analysis evaluated patient and treatment characteristics. Patients were randomly allocated into training (80%) or validation sets (20%). Coefficients generated a mathematical model to predict 5- and 10-year disease-specific survival (DSS).

Results

The mean DSS was 15.5 years with a 5- and 10-year DSS of 99.3% and 98.6%, respectively. Age, sex, race, median household income (MHI), tumor size, and nodal status were significant on mul

SUBMITTER: Nielsen S 

PROVIDER: S-EPMC11994147 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature