Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia.

ABSTRACT:

Background

Writer's cramp (WC) dystonia is an involuntary movement disorder with distributed abnormalities in the brain's motor network. Prior studies established the potential for repetitive transcranial magnetic stimulation (rTMS) to either premotor cortex (PMC) or primary somatosensory cortex (PSC) to modify symptoms. However, clinical effects have been modest with limited understanding of the neural mechanisms hindering therapeutic advancement of this promising approach.

Objective

This study aimed to understand the motor network effects of rTMS in WC that correspond with behavioral efficacy. We hypothesized that behavioral efficacy is associated with modulation of cortical and subcortical regions of the motor network.

Methods

In a double-blind, cross-over design,

SUBMITTER: Bukhari-Parlakturk N 

PROVIDER: S-EPMC11994290 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature