Stable White Matter Structure in the First Three Years After Psychosis Onset.

ABSTRACT:

Background

White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date have been cross-sectional, so despite their large sample sizes, they cannot determine whether changes accumulate as a degenerative process or patients with preexisting white matter damage are predisposed to more chronic forms of schizophrenia.

Methods

We examined 160 scans comprising 2 years of annual follow-up data from 42 control participants and 28 patients with schizophrenia recruited in the first 2 years since their diagnosis, totaling 2 to 3 scans per participant. We also examined 6-month follow-up data obtained from an ultra-high fiel

SUBMITTER: Van Dyken PC 

PROVIDER: S-EPMC11994302 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature