Role of Serum Brain-Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults.

ABSTRACT:

Background

Serum brain-derived neurotrophic factor (BDNF) has emerged as a promising biomarker for chronic pain (CP) research and treatment. Yet, most human studies have been limited by small sample sizes, inadequate control of confounders and a lack of focus on sex and mental health differences.

Methods

This study included data from 1932 community-dwelling individuals aged ≥ 65 years, randomly sampled from the Spanish general population. Serum BDNF was quantified by ELISA. CP characteristics were assessed using the European Chronic Pain Survey and classified according to electronic medical records (ICPC-2 codes). Linear regression models-adjusted for sociodemographic, lifestyle and clinical factors-and stratified analyses by sex and depression status (defined by Geriatric D

SUBMITTER: Ortola R 

PROVIDER: S-EPMC11994381 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature