Magnetic resonance imaging in glioblastoma radiotherapy - beyond treatment adaptation.

ABSTRACT:

Background and purpose

The treatment of glioblastoma remains a challenging task for modern radiation oncology. Adaptive radiotherapy potentially improves local control and reduces toxicity to healthy brain tissue. The purpose of the study was to examine the safety of adaptive radiotherapy in glioblastoma, using a margin-reduction approach based on an interim magnetic resonance image (MRI). Furthermore, it aimed to identify radiomorphological features that may correlate with disease outcome.

Materials and methods

108 glioblastoma patients receiving standard chemoradiotherapy underwent repeated MRI after 40 Gy. The images were compared to the pre-radiotherapy MRI, based on the following criteria: midline shift, perifocal edema, contrast enhancement, ventricular compression, ne

SUBMITTER: Paczona VR 

PROVIDER: S-EPMC11994382 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature