Metal-organic framework-based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2.

ABSTRACT: Porcine circovirus type 2 (PCV2) has caused massive economic losses to the global pig farming industry. As emerging nanomaterials, metal-organic frameworks (MOFs) have considerable potential in drug and vaccine delivery because of their unique physicochemical properties. Based on the successful expression and identification of PCV2 antigens (Cap protein), this study exploits MOF platforms to design a nanovaccine delivery system (Cap@ZIF-8-CpG) as a novel subunit vaccine, which effectively enhances the resistance of antigens to denaturation and boosts immune responses against PCV2. Results demonstrate that mice injected with a nanovaccine efficiently incorporating PCV2 antigens (Cap) and an immune enhancer (CpG) elicit robust humoral immune responses. Notably, immunoglobulin G antibody tite

SUBMITTER: Ding LG 

PROVIDER: S-EPMC11994384 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature