Potential Efficacy of Metformin for Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

ABSTRACT:

Topic

Metformin, a widely used diabetes medication, has shown potential for treating age-related macular degeneration (AMD) due to its antioxidative, anti-inflammatory, and antiangiogenic properties. This study aims to systematically review and analyze the efficacy of metformin in reducing AMD prevalence.

Clinical relevance

Metformin's potential to serve as a treatment for AMD could significantly reduce the burden of vision loss, offering a cost-effective and widely accessible solution.

Methods

A systematic search was conducted in OVID Embase, OVID MEDLINE, Cochrane Library, and Web of Science databases on May 2, 2024. Both observational and interventional studies were included if they involved oral metformin use before AMD diagnosis. Data were extracted and analyzed

SUBMITTER: Huh MD 

PROVIDER: S-EPMC11994399 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature