Using genetics, genomics, and transcriptomics to identify therapeutic targets in juvenile idiopathic arthritis.

ABSTRACT: Despite progress in improving outcomes for oligoarticular and polyarticular juvenile idiopathic arthritis (JIA), the field still faces considerable challenges. More than half of adults who have had JIA continue to have active disease and have developed functional limitations. Medication side effects are common and intrusive. Thus, the field continues to search for therapeutic agents that target specific aspects of disease pathobiology and will be accompanied by fewer and less intrusive side effects. We identified 28 candidate target genes that were associated with JIA according to Open Targets Genetics and were also differentially expressed in the CD4+ T cells of children with active JIA (when compared to healthy control subjects). Of the 28 candidates, the strongest new target to emerge w

SUBMITTER: Tarbell E 

PROVIDER: S-EPMC11994403 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature