Early diagnosis and risk factors of diabetic peripheral neuropathy in type 1 diabetes: insights from current perception threshold testing.

ABSTRACT:

Objective

This study investigates nerve fiber dysfunction in type 1 diabetes (T1D) patients and identifies risk factors for diabetic peripheral neuropathy (DPN). It evaluates the relationship between current perception threshold (CPT) tests and nerve conduction velocity (NCV), and assesses CPT's diagnostic accuracy for early DPN detection.

Research design and methods

This study enrolled 110 patients with T1D and 26 healthy controls between January 2020 and December 2021, in accordance with predefined inclusion/exclusion criteria. CPT testing at 2000 Hz, 250 Hz, and 5 Hz assessed Aβ, Aδ, and C fiber function, while NCV was measured in 47 patients. Subgroups were stratified by disease duration (>5 years vs ≤5 years). Multivariate logistic regression identified DPN risk factors

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11994408 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature