Tumor habitat-derived radiomics features in pretreatment CT scans for predicting concurrent chemoradiotherapy responses in nasopharyngeal carcinoma: a retrospective study.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is a highly heterogeneous malignancy, characterized by significant variability in its biological and clinical features, which contribute to diverse treatment responses among patients. This study aimed to investigate intratumoral heterogeneity (ITH) in pretreatment computed tomography (CT) scans and test its performance for predicting responses to simultaneous chemoradiotherapy treatment in NPC patients.

Methods

Pretreatment CT scans of 113 NPC patients were retrospectively analyzed at our center from March 2012 to September 2022. Radiomics features were selected from tumor and habitat regions to establish models. Both univariate and multivariate analyses were conducted to identify clinical risk indices related to treatment responses.

SUBMITTER: Yin X 

PROVIDER: S-EPMC11994483 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature