Unfavorable venous outflow correlates with poor prognosis in acute ischemic stroke due to large vessel occlusion (AIS-LVO) patients assessed dynamically and quantitatively based on four-dimensional computed tomography angiography/perfusion (4D-CTA/CTP).

ABSTRACT:

Background

The condition of cerebral venous outflow (VO) and tissue level collaterals (TLC) can indirectly reflect cerebral microvascular perfusion in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). This study aimed to investigate the association among VO, TLC, and long-term functional prognosis based on four-dimensional computed tomography angiography/perfusion (4D-CTA/CTP); and to compare the predictive value of different VO indicators for poor outcome.

Methods

Enrolled AIS-LVO patients were categorized into good and poor outcome groups based on 90-day modified Rankin Scale (mRS) score, and they all underwent 4D-CTA/CTP examination at baseline. Veins were evaluated by three indicators: (I) four-dimensional cortical venous collaterals score (4D-

SUBMITTER: Gu S 

PROVIDER: S-EPMC11994486 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature