Correlation of Parkinson's disease severity and ¹⁸F-FDG and ¹⁸F-FP-DTBZ PET.

ABSTRACT:

Background

Positron emission tomography (PET) using the tracer ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) and [¹⁸F] 9-fluoropropyl-(+)-dihydrotetrabenazine (¹⁸F-FP-DTBZ) is widely utilized to measure metabolic activity and dopaminergic integrity in neurodegenerative diseases such as Parkinson's disease (PD). Previous studies employing ¹⁸F-FDG PET have primarily focused on motor or non-motor symptoms, rather than the severity of PD. This study aimed to measure the glucose metabolism of ¹⁸F-FDG and the dopaminergic function of ¹⁸F-FP-DTBZ across various Hoehn-Yahr (H&Y) stages, analyzing the correlation between metabolic activity, dopaminergic function, and H&Y stages to monitor the severity of PD.

Methods

The

SUBMITTER: Li S 

PROVIDER: S-EPMC11994490 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature