Impaired glymphatic system in patent foramen ovale based on diffusion tensor imaging analysis along the perivascular space.

ABSTRACT:

Background

Patent foramen ovale (PFO) is often complicated by cerebral diseases. Notably, PFO is disproportionately prevalent in cryptogenic stroke patients, but the mechanism of PFO is not clear yet. This study aimed to investigate whether there was a decline in the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index that partially indicates interstitial fluid (ISF) dynamics and glymphatic system function in PFO patients, which had not been reported before, and to discuss the glymphatic metabolism mechanism by which PFO causes cryptogenic stroke.

Methods

In total, 52 PFO patients and 50 age- and gender-matched healthy controls (HCs) who underwent diffusion tensor imaging (DTI) with magnetic resonance imaging (MRI) scanning were included in the st

SUBMITTER: Sun L 

PROVIDER: S-EPMC11994554 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature