Multimodal radiomics based on fluorine-18 prostate-specific membrane antigen positron emission tomography and multiparametric magnetic resonance imaging in predicting persistent prostate-specific antigen after radical prostatectomy.

ABSTRACT:

Background

Persistent prostate-specific antigen (PSA) after radical prostatectomy (RP) is associated with increased metastasis and mortality. However, the value of the radiomics for predicting persistent PSA is unclear. Our study aimed to evaluate the diagnostic performance of ¹⁸F-PSMA-1007 positron emission tomography (PET) and multiparametric magnetic resonance imaging (mpMRI) radiomics for the prediction of persistent PSA after RP.

Methods

Retrospective analysis was performed on 141 patients with prostate cancer (PCa) who had undergone ¹⁸F-prostate-specific membrane antigen (PSMA)-1007 PET and mpMRI scans before RP. Patients were placed into two groups according to PSA levels examined within 4-8 weeks after surgery: a nonpersistent PSA group and a pe

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC11994558 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature