Increased TIGIT expression correlates with impaired NK cell function in diffuse large B-cell lymphoma.

ABSTRACT:

Purpose

This study aims to investigate the status of natural killer (NK) cells and the role of T-cell immunoreceptor with Ig and ITIM domains (TIGIT)-mediated regulation in diffuse large B-cell lymphoma (DLBCL).

Methods

Peripheral blood samples from 30 newly diagnosed DLBCL patients and 25 healthy controls were collected. Multiparametric flow cytometry was used to analyze the expression levels of TIGIT and its family molecules (CD226 and CD96) on NK cells, as well as to assess NK cell phenotype and function. The restorative effects of TIGIT blockade on NK cell cytotoxicity were evaluated through in vitro functional assays and in vivo animal models.

Results

Compared to healthy controls, DLBCL patients exhibited significantly reduced percentages and absolu

SUBMITTER: Lu H 

PROVIDER: S-EPMC11994634 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature