Towards whole brain mapping of the hemodynamic response function.

ABSTRACT: Functional magnetic resonance imaging time-series are conventionally processed by linear modelling the evoked response as the convolution of the experimental conditions with a stereotyped hemodynamic response function (HRF). However, the neural signal in response to a stimulus can vary according to task, brain region, and subject-specific conditions. Moreover, HRF shape has been suggested to carry physiological information. The BOLD signal across a range of sensorial and cognitive tasks was fitted using a sine series expansion, and modelled signals were deconvolved, thus giving rise to a task-specific deconvolved HRF (dHRF), which was characterized in terms of amplitude, latency, time-to-peak and full-width at half maximum for each task. We found that the BOLD response shape changes not on

SUBMITTER: Mangini F 

PROVIDER: S-EPMC11994648 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature