A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression.

ABSTRACT: Hypertension-related Depression (HD) is a complex mental disorder that exerts a significant negative impact on patients' quality of life. Previous studies have demonstrated that damages to vascular endothelial and hippocampus are the primary pathological features in HD rats. Under hypertensive conditions, inflammatory cytokines in peripheral blood vessels can induce central nervous system inflammation through penetration of a damaged blood-brain barrier, peripheral immune cells, and neural pathways, damaging the brain and triggering HD. Therefore, interactions between vascular endothelial cells, neurons, and glial cells are critical for the understanding of HD. However, in vivo animal models are often limited by the complexity of intrinsic systems, high inter-individual variability,

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11994666 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature