Immunogenicity of <i>Pv</i>Vir14-derived peptides to improve the serological diagnosis of <i>Plasmodium vivax</i> infection.

ABSTRACT:

Introduction

Malaria, caused by Plasmodium vivax, remains a major global health problem, particularly in tropical and subtropical regions. This study aimed to investigate the potential of PvVir14-derived peptides to improve diagnostic accuracy for P. vivax infections.

Methods

The reactivity of specific PvVir14-derived peptides against sera from acutely infected individuals from endemic and non-endemic areas experiencing a P. vivax malaria outbreak was assessed, as well as their sensitivity, specificity, and immunodominance.

Results

Among the eight tested peptides (H08, K09, I03, G08, F08, H04, L06, and N04), H08, G08, and L06 showed significantly higher IgG reactivity in sera from individuals living in endemic areas, mainly within th

SUBMITTER: Brito RMM 

PROVIDER: S-EPMC11994686 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature