ESCRT may function as a tumor biomarker, transitioning from pan-cancer analysis to validation within breast cancer.

ABSTRACT:

Background

Studies have shown that ESCRT genes affect cell aging, immune environment, and tumors. BRCA was used to explore its effects on tumor prognosis and therapy.

Methods

The data sets of Cancer Genome Atlas (TCGA), Genome-Tissue Expression Plan (GTEX), Human Protein Mapping (HPA), Gene Expression Omnibus (GEO), Clinical Proteomic Tumor Analysis Consortium (CPTAC), R software package, and bioinformatics methods were used to mine the potential carcinogenic effects of ESCRT, including the expression level, prognostic value, and immune value of ESCRT in various types of tumor tissues, and the potential function of ESCRT family genes was further verified in breast cancer.

Results

ESCRT showed significant differential expression in various cancers, such as bladder urot

SUBMITTER: Chen XR 

PROVIDER: S-EPMC11994712 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature