Berberine alleviates atherosclerosis by modulating autophagy and inflammation through the RAGE-NF-κB pathway.

ABSTRACT:

Introduction

Lipid accumulation and foam cell formation are significant features that expedite the progression of atherosclerosis (AS). Abnormal autophagy is a key factor in the development of AS. The importance of berberine (BBR) in AS has been well established. However, its exact role in regulating autophagy and alleviating atherosclerotic inflammation remains unclear.

Purpose

This study was aimed at exploring the role and mechanism of BBR in alleviating AS by activating autophagy and alleviating inflammation.

Study design

Network pharmacology predicts the potential mechanism of BBR in regulating AS and verifies this mechanism through in vivo and in vitro experiments, thereby providing new thinking for clinical treatment.

Methods

The potential m

SUBMITTER: Zhang P 

PROVIDER: S-EPMC11994719 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature