Comprehensive analysis of UPK3B as a marker for prognosis and immunity in pancreatic adenocarcinoma.

ABSTRACT: The low immunogenicity of pancreatic cancer inhibits effective antitumor immune responses, primarily due to the immune evasion mediated by low expression of the major histocompatibility complex (MHC). Through comprehensive analysis, our study identifies UPK3B as a gene closely associated with low MHC expression and low immunogenicity in pancreatic cancer. UPK3B has been reported as a marker of primary mesothelial cells, mature epicardium and promotes extracellular matrix signaling. However, the role of UPK3B in pancreatic cancer remain unclear. We found that UPK3B is highly predictive of overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC) and is significantly related to clinical features, immune cell infiltration, and response to immune checkpoint inhibitor (ICI)

SUBMITTER: Jian Z 

PROVIDER: S-EPMC11994762 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature