Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not <i>β</i>-accumulation in older adults: an exploratory study.

ABSTRACT:

Introduction

Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.

Methods

At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.

Results

AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.

Discussion

AL i

SUBMITTER: Palix C 

PROVIDER: S-EPMC11994863 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature