Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death in the worldwide. Although cisplatin and other platinum-based drugs are widely used as radiosensitizers in radiotherapy and considered the first-line treatment for advanced lung cancer, their clinical utility is often limited by drug resistance and severe cytotoxic side effects. In recent years, iridium-based complexes and other transition metal cation complexes with similar structural properties have garnered increasing research interest due to their potential anticancer properties.

Methods

Recently, we synthesized a novel iridium (III) complex (Ir-1) and evaluated its safety and stability. The present study aimed to identify Ir-1 with potent anticancer activity by assessing its cytotoxic effects on lung ca

SUBMITTER: Pang Y 

PROVIDER: S-EPMC11994930 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature