Apoptotic vesicles inhibit bone marrow adiposity via wnt/β-catenin signaling.

ABSTRACT:

Background

There is currently increasing focus on aging-related diseases. Osteoporosis is a common disease the incidence of which increases with age. In older patients with osteoporosis, bone marrow mesenchymal stem cells (BMMSCs) have a decreased capacity for osteogenesis and an increased capacity for adipogenesis, causing excessive accumulation of adipose tissue in the bone marrow. Therefore, means of reducing bone marrow adiposity may have therapeutic potential for osteoporosis. Apoptotic vesicles (apoVs) participate in a wide range of physiological processes and have been shown to have therapeutic effects in a variety of diseases. The principal objective of this study was to examine the special properties and regulatory mechanisms of BMMSC-derived apoVs in the treatment of bone

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11994938 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature