DeepHeteroCDA: circRNA-drug sensitivity associations prediction via multi-scale heterogeneous network and graph attention mechanism.

ABSTRACT: Drug sensitivity is essential for identifying effective treatments. Meanwhile, circular RNA (circRNA) has potential in disease research and therapy. Uncovering the associations between circRNAs and cellular drug sensitivity is crucial for understanding drug response and resistance mechanisms. In this study, we proposed DeepHeteroCDA, a novel circRNA-drug sensitivity association prediction method based on multi-scale heterogeneous network and graph attention mechanism. We first constructed a heterogeneous graph based on drug-drug similarity, circRNA-circRNA similarity, and known circRNA-drug sensitivity associations. Then, we embedded the 2D structure of drugs into the circRNA-drug sensitivity heterogeneous graph and use graph convolutional networks (GCN) to extract fine-grained embeddings

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11995009 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature