Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant <i>Acinetobacter baumannii</i> Clinical Isolates.

ABSTRACT: Acinetobacter baumannii is classified as a highest threat pathogen, urgently necessitating novel antimicrobials that evade resistance to combat its spread. Quaternary ammonium compounds (QACs) have afforded a valuable first line of defense against antimicrobial resistant pathogens as broad-spectrum amphiphilic disinfectant molecules. However, a paucity of innovation in this space has driven the emergence of QAC resistance. Through this work, we sought to identify next-generation disinfectant molecules with efficacy against highly resistant A. baumannii clinical isolates. We selected 12 best-in-class molecules from our previous investigations of quaternary ammonium and quaternary phosphonium compounds (QPCs) to test against a panel of 35 resistant A. baumannii clinical

SUBMITTER: Michaud ME 

PROVIDER: S-EPMC11995017 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature