Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease.

ABSTRACT: Age-related macular degeneration (AMD) represents a major global health burden, with current estimates suggesting that up to 200 million people are affected globally. While effective treatments exist for the exudative form of the disease termed choroidal neovascular AMD, there remain challenges associated with long-term responses to treatment and the ongoing parallel development of the non-exudative form of AMD. Here, we sought to develop an approach for long-term delivery of both aflibercept, a decoy receptor that neutralises vascular endothelial growth factor and a concomitant treatment focused on treating the non-exudative form of AMD. To this end, we developed a series of induced pluripotent stem cell (iPS)-derived retinal pigment epithelial (RPE) cell lines that stably expressed aflib

SUBMITTER: Reddy A 

PROVIDER: S-EPMC11995081 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature