A cerium nanocluster for effective alleviation of inflammatory bowel disease by scavenging RONS and regulating gut microbiome.

ABSTRACT: Inflammatory bowel disease (IBD) is characterized by excessive generation of reactive oxygen species and reactive nitrogen species (RONS) within the pro-inflammatory microenvironment. Conventional treatments often have serious side effects, making IBD management challenging. Here, a new cerium cluster, Ce12, with a formula of [Ce₁₂(μ ₃-O)₈(μ ₃-OH)₈(μ ₂-OH)₆(ADA)₁₈]∙3H₂O∙3CH₃CN (ADA^- = 1-adamantanecarboxylate) was prepared and capped with β-cyclodextrin (β-CD) through self-assembly process involving the adamantane moiety of Ce12 and β-CD, resulting in Ce12@CD nanoparticles (NPs). Ce12@CD NPs, with good stability and biocompatibility, exhibit excellent

SUBMITTER: Yang D 

PROVIDER: S-EPMC11995134 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature