Identify key transcript factors of adipocyte differentiation in abdominal fat of broilers based on ATAC-seq and RNA-seq.

ABSTRACT: Intensive breeding has resulted in excessive deposition of abdominal fat tissue (AFT) in broilers, leading to significant economic loss in the poultry industry. Understanding the molecular mechanisms underlying AFT development is essential for informed breeding strategies. In the current study, we elucidated dynamic changes of chromatin accessibility and transcriptional reprogramming in AFT at D14 and D42 in broilers based on integrated analysis of RNA-seq and ATAC-seq. RNA-seq analysis manifested significant transcriptional differences in AFT development, identifying 1323 up- and 1285 down-regulated differential expression genes (DEGs) as well as 63 up- and 58 down-regulated transcription factors (TFs) at D42 compared to those at D14. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysi

SUBMITTER: Liu X 

PROVIDER: S-EPMC11995140 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature