Megastigmanes isolated from <i>Boehmeria nivea</i> leaves and their immunomodulatory effect on IL-1β and IL-10 production in RAW264.7 macrophages.

ABSTRACT: With the aim of isolating immunomodulatory compounds from the n-butanol extract of Boehmeria nivea leaves, nine megastigmane compounds were identified. Among these, the structure of the new compound 1, namely, "boehmegaside A", was established using NMR and HR-ESI-MS, and its absolute configurations were established through ECD calculations and DP4+ analysis using DFT-NMR chemical shift calculations. Furthermore, eight of these compounds were discovered for the first time in the Boehmeria genus, marking this the first report on megastigmane compounds isolated from this genus. Regarding their immunomodulatory activity, the isolated megastigmane compounds 3, 2, and 6 exhibited pro-inflammatory cytokine IL-1β secretion inhibitory activity. Compounds 3 and 6 significantly

SUBMITTER: Nguyen TTT 

PROVIDER: S-EPMC11995158 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature