Microstructurally informed subject-specific parcellation of the corpus callosum using axonal water fraction.

ABSTRACT: The corpus callosum (CC) is the most important interhemispheric white matter (WM) structure composed of several anatomically and functionally distinct WM tracts. Resolving these tracts is a challenge since the callosum appears relatively homogenous in conventional structural imaging. Commonly used callosal parcellation methods such as Hofer and Frahm scheme rely on rigid geometric guidelines to separate the substructures that are limited to consider individual variation. Here we present a novel subject-specific and microstructurally-informed method for callosal parcellation based on axonal water fraction (ƒ) known as a diffusion metric reflective of axon caliber and density. We studied 30 healthy subjects from the Human Connectome Project dataset with multi-shell diffusion MRI. The biophys

SUBMITTER: Chung S 

PROVIDER: S-EPMC11995408 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature