Deciphering the anti‑influenza potential of Eucommiae Cortex based on bioinformatics analysis: <i>In silico</i> and <i>in vitro</i> experiments.

ABSTRACT: Influenza infections damage the airway and induce the innate immune response that contributes to hyper-inflammation. Eucommiae Cortex (EC) enhances immune function and suppresses inflammation. To determine potential compounds and targets of EC associated with influenza, bioinformatics analyses and experimental verification were employed. The active compounds of EC were retrieved from the Traditional Chinese Medicine Systems Pharmacology database. The intersecting targets of EC and influenza were determined and examined using network pharmacology to analyze the relationship between the compounds and disease targets. The network identified three main compounds (quercetin, genistein and kaempferol) and four main targets (IL6, BCL2, IL1B and TNF). The ligand-target binding affinity was calcula

SUBMITTER: Nowakowska A 

PROVIDER: S-EPMC11995446 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature