Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood.

ABSTRACT:

Background

Although the associations between cord blood lipidome and neonatal birth weight are established, it remains uncertain whether sexual dimorphism in fetal fat accumulation extends to the relationship between cord blood lipid profiles and neonatal abdominal fat compartments. Understanding these relationships could provide insights into early sex-specific differences in lipid metabolism.

Methods

We conducted lipidomics of umbilical cord blood plasma samples (350 (46.6%) girls and 401 (53.4%) boys) from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort. Abdominal fat compartments-superficial subcutaneous adipose tissue (sSAT), deep SAT (dSAT), and intra-abdominal adipose tissue (IAT)-were quantified by magnetic resonance imaging within 2 weeks o

SUBMITTER: Narasimhan K 

PROVIDER: S-EPMC11995507 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature