Estimating mutation rate and characterising single nucleotide de novo mutations in pigs.

ABSTRACT:

Background

Direct estimates of mutation rates in humans have changed our understanding of evolutionary timing and de novo mutations (DNM) have been associated with several developmental disorders in humans. Livestock species, including pigs, can contribute to the study of DNM because of their ideal population structure and routine phenotype collection. In principle, there is the potential for livestock populations to quickly accumulate new genetic variants because of short generation intervals and high selection intensity. However, the impact of DNM on the fitness of individuals is not known and with current genomic selection programs they cannot contribute to estimated breeding values. The aims of our project were to detect and validate single nucleotide DNM in two commercial pig

SUBMITTER: Rochus CM 

PROVIDER: S-EPMC11995543 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature