Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer's disease.

ABSTRACT:

Background

The identification and intervention of Alzheimer's Disease (AD) in its early-stage allows for the timely implementation of lifestyle modifications and therapeutic strategies. Although dysregulation of protein expression has been reported in the brain from AD patients and AD animal models, the underlying mechanisms remain poorly understood. N4-acetylcytidine (ac4C), the only known form of RNA acetylation in eukaryotes, has recently been shown to regulate mRNA stability and translation efficiency. However, the dysregulation of ac4C associated with abnormal protein expression levels in the brain of early-stage mouse models of AD remains to be elucidated.

Methods

This study investigated ac4C modifications, mRNA and protein expression in the hippocampus of 3 and 6-mont

SUBMITTER: Ji HN 

PROVIDER: S-EPMC11995559 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature