Gallium nitrate inhibits multidrug-resistant Acinetobacter baumannii isolated from bloodstream infection by disrupting multiple iron-dependent metabolic processes.

ABSTRACT:

Background

Acinetobacter baumannii is a major pathogen in hospitals, causing a notable rise in bloodstream infections among inpatients. Its growing resistance to multiple drugs limits treatment options. This study aims to examine the antibacterial effects of gallium nitrate [Ga(NO₃)₃] against A. baumannii and elucidate the underlying molecular mechanism.

Methods

40 strains of A. baumannii with different antimicrobials susceptibility patterns were isolated from bloodstream infections. The in vitro antibacterial activity of Ga(NO₃)₃ was analyzed by micro-dilution method and time-kill assay. The influence of ferric chloride/hemin on the antibacterial efficacy of Ga(NO₃)₃ was investigated. Transcriptome sequencing

SUBMITTER: Yao Z 

PROVIDER: S-EPMC11995626 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature