Integrative eQTL and Mendelian randomization analysis reveals key genetic markers in mesothelioma.

ABSTRACT:

Background

Mesothelioma is a rare cancer that originates from the pleura and peritoneum, with its incidence increasing due to asbestos exposure. Patients are frequently diagnosed at advanced stages, resulting in poor survival rates. Therefore, the identification of molecular markers for early detection and diagnosis is essential.

Methods

Three mesothelioma datasets were downloaded from the GEO database for differential gene expression analysis. Instrumental variables (IVs) were identified based on expression quantitative trait locus (eQTL) data for Mendelian randomization (MR) analysis using mesothelioma Genome-Wide Association Study (GWAS) data from the FINNGEN database. The intersecting genes from MR-identified risk genes and differentially expressed genes were identified

SUBMITTER: Li J 

PROVIDER: S-EPMC11995628 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature