Targeting the Epigenome Reduces Keloid Fibroblast Cell Proliferation, Migration, and Invasion.

ABSTRACT: Keloids are pathological fibroproliferative scars resulting from abnormal collagen deposition within and beyond the margins of the initial cutaneous insult. Keloids negatively impact QOL functionally and cosmetically, with current treatment modalities unsatisfactory. Recent studies indicate that epigenetic dysregulation is central to the development and progression of keloids. In this study, we evaluate the functional significance of epigenetic targeting strategies in vitro using patient-derived keloid fibroblasts treated with small-molecule inhibitors of histone deacetylases, LSD1, CoREST, and p300, as potential therapies for keloids. We find that both the dual-acting CoREST inhibitor corin and the histone deacetylase inhibitor entinostat reduce fibroblast proliferation more than the LSD1

SUBMITTER: Almier N 

PROVIDER: S-EPMC11995714 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature