Impact of rosuvastatin on the memory potential and functionality of CD8⁺ T cells from people with HIV.

ABSTRACT:

Background

Virus-specific CD8⁺ T cells play a major role in the natural control of HIV infection, linked to memory-like features such as high survival capacity and polyfunctionality. However, virus-specific CD8⁺ T cells from HIV non-controllers exhibit an effector-like and exhausted profile, with limited antiviral potential. Metabolic reprogramming of cells from non-controllers could reinvigorate their functional capacities. Considering the implication of the cholesterol pathway in the induction of T cell exhaustion, here we evaluated the impact of rosuvastatin, an inhibitor of cholesterol synthesis, on the functionality and memory profile of HIV-specific CD8⁺ T cells from people on antiretroviral treatment.

Methods

We analysed samples from 1

SUBMITTER: Perdomo-Celis F 

PROVIDER: S-EPMC11995788 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature