Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia.

ABSTRACT:

Background

Developing non-invasive and affordable biomarkers to detect Alzheimer's disease (AD) at a prodromal stage is essential, particularly in the context of new disease-modifying therapies. Mild cognitive impairment (MCI) is a critical stage preceding dementia, but not all patients with MCI will progress to AD. This study explores the potential of magnetoencephalography (MEG) to predict cognitive decline from MCI to AD dementia.

Methods

We analysed resting-state MEG data from the BioFIND dataset including 117 patients with MCI among whom 64 developed AD dementia (AD progression), while 53 remained cognitively stable (stable MCI), using spectral analysis. Logistic regression models estimated the additive explanation of selected clinical, MEG, and MRI variables for AD pro

SUBMITTER: Gaubert S 

PROVIDER: S-EPMC11995804 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature