COPASAAR--a database for proteomic analysis of single amino acid repeats.

ABSTRACT:

Background

Single amino acid repeats make up a significant proportion in all of the proteomes that have currently been determined. They have been shown to be functionally and medically significant, and are associated with cancers and neuro-degenerative diseases such as Huntington's Chorea, where a poly-glutamine repeat is responsible for causing the disease. The COPASAAR database is a new tool to facilitate the rapid analysis of single amino acid repeats at a proteome level. The database aims to simplify the comparison of repeat distributions between proteomes in order to provide a better understanding of their function and evolution.

Results

A comparative analysis of all proteomes in the database (currently 244) shows that single amino acid repeats account for about 12-14%

SUBMITTER: Depledge DP 

PROVIDER: S-EPMC1199582 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature