Combating oxi-inflamm-aging: Passerini adducts tethered with 1,2,3-triazoles for enhanced antioxidant defense and 5-LOX inhibition.

ABSTRACT: Oxi-inflamm-aging, a term describing the interplay between chronic oxidative stress and inflammation, is a key contributor to cellular deterioration and age-related diseases (ARDs). To target these interconnected mechanisms, we designed and synthesized novel hybrids of Passerini adducts tethered with 1,2,3-triazoles, inspired by the naturally isolated dipeptide aurantiamide acetate known for its dual anti-inflammatory and antioxidant properties. The adducts were synthesized via an optimized one-pot reaction of 4-nitrophenylisonitrile, cyclohexanone, and appropriate carboxylic acids under Passerini three-component reaction (Passerini-3CR) conditions, followed by the installation of structurally diverse 1,2,3-triazoles onto the α-acyloxy carboxamides through click chemistry. Biologica

SUBMITTER: Ayoup MS 

PROVIDER: S-EPMC11995860 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature