Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors.

ABSTRACT:

Background

Somatic mutations in the mitochondrial genome occur in numerous tumor types including brain tumors. These mutations are generally found in the hypervariable regions I and II of the displacement loop and unlikely alter mitochondrial function. Two hypervariable regions of mononucleotide repeats occur in the mouse mitochondrial genome, i.e., the origin of replication of the light strand (OL) and the Arg tRNA.

Methods

In this study we examined the entire mitochondrial genome in a series of chemically induced brain tumors in the C57BL/6J strain and spontaneous brain tumors in the VM mouse strain. The tumor mtDNA was compared to that of mtDNA in brain mitochondrial populations from the corresponding syngeneic mouse host strain.

Results

Direct sequencing revealed

SUBMITTER: Kiebish MA 

PROVIDER: S-EPMC1199588 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature