An alternative cell cycle coordinates multiciliated cell differentiation.

ABSTRACT: The canonical mitotic cell cycle coordinates DNA replication, centriole duplication and cytokinesis to generate two cells from one¹. Some cells, such as mammalian trophoblast giant cells, use cell cycle variants like the endocycle to bypass mitosis². Differentiating multiciliated cells, found in the mammalian airway, brain ventricles and reproductive tract, are post-mitotic but generate hundreds of centrioles, each of which matures into a basal body and nucleates a motile cilium^3,4. Several cell cycle regulators have previously been implicated in specific steps of multiciliated cell differentiation^5,6. Here we show that differentiating multiciliated cells integrate cell cycle regulators into a new alternative cell cycle, which we refer to as the

SUBMITTER: Choksi SP 

PROVIDER: S-EPMC11996048 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature