Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice.

ABSTRACT: Transcranial direct-current stimulation (tDCS) of the cerebellum is a promising non-invasive neuromodulatory technique being proposed for the treatment of neurological and neuropsychiatric disorders. However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of Purkinje cells (PC) and non-PC in the mouse cerebellar cortex to understand the underlying mechanisms behind the polarity-dependent modulation of neuronal activity induced by tDCS. Mice (n=9) were prepared for the chronic recording of local field potentials (LFPs) to assess the actual electric field gradient imposed by Cb-tDCS in our experimental design. Single-neuron extracellular recording of PCs in

SUBMITTER: Sanchez-Leon CA 

PROVIDER: S-EPMC11996176 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature